Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0104
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
  GARGAN PAUL E
 2. Date of Event Requiring Statement (Month/Day/Year)
03/02/2009		 3. Issuer Name and Ticker or Trading Symbol
GEN PROBE INC [GPRO]
(Last)
(First)
(Middle)
GEN-PROBE INCORPORATED, 10210 GENETIC CENTER DRIVE		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
SVP, Business Dev.
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

SAN DIEGO, CA 92121		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 18,697
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (Right to Buy)   (1) 08/15/2013 Common Stock 4,342 $ 29.525 D  
Employee Stock Option (Right to Buy)   (1) 09/13/2014 Common Stock 1,910 $ 36.59 D  
Employee Stock Option (Right to Buy)   (2) 10/17/2015 Common Stock 6,250 $ 42.5 D  
Employee Stock Option (Right to Buy)   (3) 08/15/2013 Common Stock 15,000 $ 49.29 D  
Employee Stock Option (Right to Buy)   (4) 08/15/2014 Common Stock 18,000 $ 60.82 D  
Employee Stock Option (Right to Buy)   (5) 08/15/2015 Common Stock 13,500 $ 60.15 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
GARGAN PAUL E
GEN-PROBE INCORPORATED
10210 GENETIC CENTER DRIVE
SAN DIEGO, CA 92121		       SVP, Business Dev.  

Signatures

/s/ R. William Bowen, Attorney-in-Fact 03/12/2009
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The stock option is fully vested and exercisable.
(2) 4,250 of the shares subject to the stock option are exercisable as of the date hereof. The remaining shares vest in equal monthly installments, such that the option will be fully vested and exercisable on 10/17/09.
(3) 9,375 of the shares subject to the stock option are exercisable as of the date hereof. The remaining shares vest in equal monthly installments, such that the option will be fully vested and exercisable on 8/15/10.
(4) 6,750 of the shares subject to the stock option are exercisable as of the date hereof. The remaining shares vest in equal monthly installments, such that the option will be fully vested and exercisable on 8/15/11.
(5) 25% of the shares subject to the stock option vest and become exercisable on 8/15/09. Thereafter, the remaining shares vest in 36 equal monthly installments, such that the option will be fully vested and exercisable on 8/15/12.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.