FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: January 31, 2005 Estimated average burden hours per response... 0.5

(Print or Type Responses)

1. Name and Address of Reporting Person * SHARER KEVIN W   2. Issuer Name and Ticker or Trading Symbol AMGEN INC [AMGN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) Chairman of the Bd, CEO & Pres (Last) (First) (Middle) ONE AMGEN CENTER DRIVE 3. Date of Earliest Transaction (Month/Day/Year) 04/29/2005 (Street) THOUSAND OAKS, CA 91320-1799 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 04/29/2005   M   3,052 A $ 16.375 3,052 D   Common Stock 04/29/2005   M   1,642 A $ 30.4375 4,694 D   Common Stock 04/29/2005   M   2,608 A $ 38.36 7,302 D   Common Stock 04/29/2005   M   22,358 A $ 30.4375 29,660 D   Common Stock 04/29/2005   M   4,000 A $ 38.36 33,660 D   Common Stock 04/29/2005   G V 33,660 (1) D $ 0 0 D   Common Stock 04/29/2005   G V 33,660 (1) A $ 0 66,751 (2) I Living Trust Common Stock 04/29/2005   I   3,224.201 A $ 0 3,224.201 (3) I By 401(k) Plan

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.		SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

ISO (Right to Buy)

$ 16.375

04/29/2005

M

3,052

07/01/2003

07/01/2005

Common Stock

3,052

$ 0

0

D

ISO (Right to Buy)

$ 30.4375

04/29/2005

M

1,642

07/01/2004

07/01/2006

Common Stock

1,642

$ 0

0

D

ISO (Right to Buy)

$ 38.36

04/29/2005

M

2,608

07/01/2003

07/01/2009

Common Stock

2,608

$ 0

1

D

NQSO (Right to Buy)

$ 30.4375

04/29/2005

M

22,358

07/01/2001

07/01/2006

Common Stock

22,358

$ 0

0

D

NQSO (Right to Buy)

$ 38.36

04/29/2005

M

4,000

07/01/2003

07/01/2009

Common Stock

4,000

$ 0

375,159

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
SHARER KEVIN W ONE AMGEN CENTER DRIVE THOUSAND OAKS, CA 91320-1799	X		Chairman of the Bd, CEO & Pres

Signatures

/s/ N. Cris Prince, By Power of Attorney		05/02/2005
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	(KWS 4.29.05) Transfer of shares into reporting person's living trust.
(2)	(KWS 2.14.05) The amount of the Company's Common Stock beneficially owned has been adjusted to reflect an acquisition by the reporting person of the Company's Common Stock under the 423(b) Plan in a transaction exempt pursuant to Rule 16a-3(f)(1)(k)(B) and subsequent transfer of such shares to reporting person's living trust.
(3)	(KWS 401(k)) These are units acquired under the Company's 401(k) Plan and represent interests in the Company's stock fund.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.