Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Prospect Venture Partners III L P
  2. Issuer Name and Ticker or Trading Symbol
COMPLETE GENOMICS INC [GNOM]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O PROSPECT VENTURE PARTNERS, 435 TASSO STREET, SUITE 200
3. Date of Earliest Transaction (Month/Day/Year)
11/16/2010
(Street)

PALO ALTO, CA 94301
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, par value $0.001 11/16/2010   C   601,248 A (1) 601,248 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   C   160,552 A (3) 761,800 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   C   674,426 A (4) 1,436,226 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   C   807,760 A (4) 2,243,986 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   X   29,343 A $ 7.56 2,273,329 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   F   24,649 D $ 9 2,248,680 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   X   31,299 A $ 7.56 2,279,979 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   F   26,292 D $ 9 2,253,687 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   X   10,240 A $ 7.56 2,263,927 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   F   8,602 D $ 9 2,255,325 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   X   990 A $ 7.56 2,256,315 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   F   832 D $ 9 2,255,483 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   P(8)   333,333 A $ 9 2,994,358 I See Footnote (2)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series B Preferred Stock (1) (1) 11/16/2010   C     601,248   (5)   (6) Common Stock 601,248 (1) 0 I See Footnote (2)
Series C Preferred Stock (3) (3) 11/16/2010   C     160,552   (5)   (6) Common Stock 160,552 (3) 0 I See Footnote (2)
Series D Preferred Stock (4) (4) 11/16/2010   C     674,426   (5)   (6) Common Stock 674,426 (4) 0 I See Footnote (2)
Series E Preferred Stock (4) (4) 11/16/2010   C     807,760   (5)   (6) Common Stock 807,760 (4) 0 I See Footnote (2)
Warrant to Purchase Series D Preferred Stock (4) $ 7.56 11/16/2010   X     29,343   (7) 02/13/2014 Common Stock 29,343 $ 0 0 I See Footnote (2)
Warrant to Purchase Series D Preferred Stock (4) $ 7.56 11/16/2010   X     31,299   (7) 04/06/2014 Common Stock 31,299 $ 0 0 I See Footnote (2)
Warrant to Purchase Series D Preferred Stock (4) $ 7.56 11/16/2010   X     10,240   (7) 06/12/2014 Common Stock 10,240 $ 0 0 I See Footnote (2)
Warrant to Purchase Series D Preferred Stock (4) $ 7.56 11/16/2010   X     990   (7) 08/05/2014 Common Stock 990 $ 0 0 I See Footnote (2)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Prospect Venture Partners III L P
C/O PROSPECT VENTURE PARTNERS
435 TASSO STREET, SUITE 200
PALO ALTO, CA 94301
    X    
Prospect Management Co. III, L.L.C.
435 TASSO STREET
SUITE 200
PALO ALTO, CA 94301
    X    

Signatures

 /s/ Alexander E. Barkas, Managing Director, Prospect Management Co. III, LLC, its General Partner for PROSPECT VENTURE PARTNERS III. L.P.   11/16/2010
**Signature of Reporting Person Date

 /s/ Alexander E. Barkas, Managing Director for PROSPECT MANAGEMENT CO. III, LLC   11/16/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Each share of Series B Preferred Stock was automatically converted into common stock immediately prior to the completion of the Issuer's initial public offering. Shares are reported on an "as-converted" basis giving effect to the 5.926613 conversion ratio applicable to such shares.
(2) The shares are owned by Prospect Venture Partners III, L.P. ("PVP III"). Prospect Management Co. III, L.L.C. ("PMC III") serves as the general partner of PVP III and possesses sole voting and investment control over the shares owned by PVP III and may be deemed to have indirect beneficial ownership of the shares held by PVP III. PMC III however owns no securities of the Issuer directly. The Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of his proportionate pecuniary interest therein.
(3) Each share of Series C Preferred Stock was automatically converted into common stock immediately prior to the completion of the Issuer's initial public offering. Shares are reported on an "as-converted" basis giving effect to the 8.241076 conversion ratio applicable to such shares.
(4) Each share of Series D and Series E Preferred Stock was automatically converted into one share of Common Stock immediately prior to the completion of the Issuer's initial public offering.
(5) The securities are immediately convertible.
(6) The expiration date is not relevant to the conversion of these securities.
(7) The warrant is immediately exercisable.
(8) PVP III purchased an additional 333,333 shares of Issuer's common stock in connection with the initial public offering at the offering price of $9.00 per share.

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