FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: January 31, 2005 Estimated average burden hours per response... 0.5

(Print or Type Responses)

1. Name and Address of Reporting Person * ENTERPRISE PARTNERS V L P   2. Issuer Name and Ticker or Trading Symbol COMPLETE GENOMICS INC [GNOM] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O ENTERPRISE PARTNERS, 2223 AVENIDA DE LA PLAYA, SUITE 300 3. Date of Earliest Transaction (Month/Day/Year) 11/16/2010 (Street) LA JOLLA, CA 92037-3218 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock, par value $0.001 11/16/2010   C   176,737 A (1) 176,737 D (2)   Common Stock, par value $0.001 11/16/2010   C   259,458 A (5) 436,195 D (2)   Common Stock, par value $0.001 11/16/2010   X   138,794 A $ 7.56 574,989 D (2)   Common Stock, par value $0.001 11/16/2010   F   23,133 D $ 9 551,856 D (2)   Common Stock, par value $0.001 11/16/2010   X   17,261 A $ 7.56 569,117 D (2)   Common Stock, par value $0.001 11/16/2010   F   14,500 D $ 9 554,617 D (2)   Common Stock, par value $0.001 11/16/2010   X   8,378 A $ 7.56 562,995 D (2)   Common Stock, par value $0.001 11/16/2010   F   7,038 D $ 9 555,957 D (2)   Common Stock, par value $0.001 11/16/2010   P(6)   111,111 A $ 9 667,068 D (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.		SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series D Preferred Stock (1)	(1)	11/16/2010		C			176,737	(3)	(4)	Common Stock	176,737	(1)	0	D (2)
Series E Preferred Stock (1)	(1)	11/16/2010		C			259,458	(3)	(4)	Common Stock	259,458	(1)	0	D (2)
Warrant to Purchase Common Stock	$ 1.5	11/16/2010		X			138,794	(5)	08/12/2016	Common Stock	138,794	$ 0	0	D (2)
Warrant to Purchase Series D Preferred Stock	$ 7.56	11/16/2010		X			17,261	(5)	04/06/2014	Common Stock	17,261	$ 0	0	D (2)
Warrant to Purchase Series D Preferred Stock	$ 7.56	11/16/2010		X			8,378	(5)	06/12/2014	Common Stock	8,378	$ 0	0	D (2)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
ENTERPRISE PARTNERS V L P C/O ENTERPRISE PARTNERS 2223 AVENIDA DE LA PLAYA, SUITE 300 LA JOLLA, CA 92037-3218		X

Signatures

/s/ Andrew E. Senyei, Managing Director, Enterprise Partners V, L.P.		11/16/2010
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Each share of Series D and Series E Preferred Stock was automatically converted into one share of Common Stock immediately prior to the completion of the Issuer's initial public offering.
(2)	The shares are owned by Enterprise Partners V, LP ("Enterprise V"). Enterprise Management Partners V, LLC ("Enterprise V LLC") serves as the general partner of Enterprise V. Andrew E. Senyei, M.D. is a managing director of Enterprise V LLC and shares voting and investment power over the shares held by Enterprise V.
(3)	The securities are immediately convertible.
(4)	The expiration date is not relevant to the conversion of these securities.
(5)	The warrant is immediately exercisable.
(6)	Enterprise V purchased an additional 111,111 shares of Issuer's common stock in connection with the initial public offering at the offering price of $9.00 per share.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.