FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: January 31, 2005 Estimated average burden hours per response... 0.5

(Print or Type Responses)

1. Name and Address of Reporting Person * DELAPE FRANK M   2. Issuer Name and Ticker or Trading Symbol ISOLAGEN INC [ILE] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner _____ Officer (give title below) __X__ Other (specify below) See General Remarks (Last) (First) (Middle) 700 GEMINI, SUITE 100 3. Date of Earliest Transaction (Month/Day/Year) 11/04/2005 (Street) HOUSTON, TX 77058 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock               673,730 I Shares are held in the name of Benchmark Equity Group, Inc., which is 100% owned by Frank M. DeLape.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.		SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Non-Qualified Stock Options

$ 6

06/18/2003

11/04/2007

Common Stock

650,000 (1)

650,000

D

Non-Qualified Stock Options

$ 4.5

02/25/2004

11/04/2010

Common Stock

400,000 (1)

400,000

D

Non-Qualified Stock Options

$ 9.81

11/04/2005

J(1)

$ 0

03/05/2005

11/04/2008

Common Stock

150,000 (1)

$ 0

150,000

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
DELAPE FRANK M 700 GEMINI SUITE 100 HOUSTON, TX 77058				See General Remarks

Signatures

/s/ Frank M. DeLape		11/08/2005
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Pursuant to a Separation and Release Agreement which was effective November 4, 2005 (the "Agreement") between Isolagen, Inc. (the "Issuer"), Isolagen Technologies, Inc. and Mr. DeLape, the Issuer and Mr. DeLape confirmed the vested and exercisable status of the Non-Qualified Stock Options reported in this Form 4. Further, under the Agreement, the parties confirmed that no other options were vested, including that 150,000 options granted in connection with the executive Employment Agreement dated September 5, 2003, as well as 400,000 options granted in connection with the Amended and Restated Employment Agreement dated July 8, 2005, were not vested and that the underlying options were deemed terminated.
Remarks: As part of the Agreement, Mr. DeLape resigned as Chairman of the Board and as a member of the Board of Directors and has terminated his employment with the Issuer.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.