Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
LEVINSON ARTHUR D
   2. Issuer Name and Ticker or Trading Symbol
GENENTECH INC [DNA] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
CHAIRMAN & CEO
(Last)
(First)
(Middle)
1 DNA WAY		 3. Date of Earliest Transaction (Month/Day/Year)
07/18/2008
(Street)

SO SAN FRANCISCO, CA 94080		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     1,700 07/16/1999(1) 07/16/2009 Common Stock 1,700 $ 0 725,305 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     300 07/16/1999(1) 07/16/2009 Common Stock 300 $ 0 725,005 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     700 07/16/1999(1) 07/16/2009 Common Stock 700 $ 0 724,305 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     500 07/16/1999(1) 07/16/2009 Common Stock 500 $ 0 723,805 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     200 07/16/1999(1) 07/16/2009 Common Stock 200 $ 0 723,605 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     600 07/16/1999(1) 07/16/2009 Common Stock 600 $ 0 723,005 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     600 07/16/1999(1) 07/16/2009 Common Stock 600 $ 0 722,405 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     600 07/16/1999(1) 07/16/2009 Common Stock 600 $ 0 721,805 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     1,300 07/16/1999(1) 07/16/2009 Common Stock 1,300 $ 0 720,505 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     600 07/16/1999(1) 07/16/2009 Common Stock 600 $ 0 719,905 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     1,300 07/16/1999(1) 07/16/2009 Common Stock 1,300 $ 0 718,605 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     302 07/16/1999(1) 07/16/2009 Common Stock 302 $ 0 718,303 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     800 07/16/1999(1) 07/16/2009 Common Stock 800 $ 0 717,503 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     800 07/16/1999(1) 07/16/2009 Common Stock 800 $ 0 716,703 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     150 07/16/1999(1) 07/16/2009 Common Stock 150 $ 0 716,553 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     3,900 07/16/1999(1) 07/16/2009 Common Stock 3,900 $ 0 712,653 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     900 07/16/1999(1) 07/16/2009 Common Stock 900 $ 0 711,753 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     2,400 07/16/1999(1) 07/16/2009 Common Stock 2,400 $ 0 709,353 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     700 07/16/1999(1) 07/16/2009 Common Stock 700 $ 0 708,653 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     1,100 07/16/1999(1) 07/16/2009 Common Stock 1,100 $ 0 707,553 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     2,800 07/16/1999(1) 07/16/2009 Common Stock 2,800 $ 0 704,753 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     600 07/16/1999(1) 07/16/2009 Common Stock 600 $ 0 704,153 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     3,200 07/16/1999(1) 07/16/2009 Common Stock 3,200 $ 0 700,953 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     294 07/16/1999(1) 07/16/2009 Common Stock 294 $ 0 700,659 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     900 07/16/1999(1) 07/16/2009 Common Stock 900 $ 0 699,759 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     1,500 07/16/1999(1) 07/16/2009 Common Stock 1,500 $ 0 698,259 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     500 07/16/1999(1) 07/16/2009 Common Stock 500 $ 0 697,759 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     993 07/16/1999(1) 07/16/2009 Common Stock 993 $ 0 696,766 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     2,100 07/16/1999(1) 07/16/2009 Common Stock 2,100 $ 0 694,666 D  
Non-Qualified Stock Option (right to buy) $ 12.13 07/18/2008   M     5,362 07/16/1999(1) 07/16/2009 Common Stock 5,362 $ 0 689,304 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
LEVINSON ARTHUR D
1 DNA WAY
SO SAN FRANCISCO, CA 94080		   X     CHAIRMAN & CEO  

Signatures

 ARTHUR D LEVINSON   07/21/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This stock option vests over three years in equal monthly increments beginning one month from grant date. This option may be immediately exercisable with the consent of Genentech.

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