Filed by Thermo Electron Corporation
Pursuant to Rule 425 under the Securities Act of 1933
And Deemed Filed Pursuant to Rule 14a-12
Under the Securities Exchange Act of 1934
Subject Company: Fisher Scientific International Inc.
Commission File No. 1-10920
The following presentations from Thermo Electron's Annual Investor Conference
on Wednesday, May 24, 2006 were posted on Thermo Electron's website.
1
FORWARD-LOOKING STATEMENTS
Information set forth in this filing contains forward-looking statements, which
involve a number of risks and uncertainties. Thermo Electron and Fisher
Scientific caution readers that any forward-looking information is not a
guarantee of future performance and that actual results could differ materially
from those contained in the forward-looking information. Such forward-
looking statements include, but are not limited to, statements about the
benefits of the business combination transaction
involving Thermo Electron
and Fisher Scientific, including future financial and operating results, the new
company's plans, objectives, expectations and intentions and other
statements that are not historical facts.
Important factors that could cause actual results to differ materially from
those indicated by such forward-looking statements are set forth in Thermo
Electron's and Fisher Scientific's filings with the SEC, including their
respective Quarterly Reports on Form 10-Q for the first quarter of 2006.
These include risks and uncertainties relating to: the ability to obtain
regulatory approvals of the transaction on
the proposed terms and schedule;
the risk that the businesses will not be integrated successfully; the risk that
2
the cost savings and any other synergies from the transaction may not be
fully realized or may take longer to realize than expected; disruption from
the transaction making it more difficult to maintain relationships with
customers,
employees or suppliers; competition and its effect on pricing,
spending, third-party relationships and revenues; the need to develop new
products and adapt to significant technological change; implementation of
strategies for improving internal
growth; use and protection of intellectual
property; dependence on customers' capital spending policies and
government funding policies; realization of potential future savings from new
productivity initiatives; dependence on customers that operate
in cyclical
industries; general worldwide economic conditions and related
uncertainties; the effect of changes in governmental regulations; exposure
to product liability claims in excess of insurance coverage; and the effect of
exchange rate
fluctuations on international operations. The parties
undertake no obligation to publicly update any forward-looking statement,
whether as a result of new information, future events or otherwise.
3
ADDITIONAL INFORMATION ABOUT THIS TRANSACTION
In connection with the proposed merger, Thermo Electron will file with the
Securities and Exchange Commission (the "SEC") a Registration Statement on
Form S-4 that will include a joint proxy statement of Thermo Electron and
Fisher Scientific that also constitutes
a prospectus of Thermo Electron. Thermo
Electron and Fisher Scientific will mail the joint proxy statement/prospectus to
their respective stockholders. Investors and security holders are urged to read
the joint proxy statement/prospectus regarding the proposed merger when it
becomes available because it will contain important information. You may
obtain a free copy of the joint proxy statement/prospectus (when available) and
other related documents filed by Thermo
Electron and Fisher Scientific with the
SEC at the SEC's Web site at www.sec.gov. The joint proxy
statement/prospectus (when it is available) and the other documents may also
be obtained for free by accessing Thermo Electron's Web site at
http://www.thermo.com
under the heading "About Thermo" and then under the
heading "Investors" or by accessing Fisher Scientific's Web site at
http://www.fisherscientific.com under the tab "Investor Info."
4
Thermo Electron, Fisher Scientific and their respective directors and
executive officers may be soliciting proxies from stockholders in favor of the
merger. Information regarding the persons
who may, under the rules of the
SEC, be considered participants in the solicitation of the stockholders in
connection with the proposed merger will be set forth in the joint proxy
statement/prospectus when it is filed with the SEC. You can find information
about Thermo Electron's executive officers and directors in Thermo
Electron's definitive proxy statement filed with the SEC on April 11, 2006.
You can find information about Fisher Scientific's
executive officers and
directors in their definitive proxy statement filed with the SEC on April 6,
2006. You can obtain free copies of these documents from Thermo
Electron or Fisher Scientific using the contact information above.
5
World Leader in Analytical Instruments
Marijn E. Dekkers
President & CEO
2006 Annual Investor Conference
May 24, 2006
Summary
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in Appendix A, which
is also available on the companys
website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1 2006. Adjusted items also include pro-forma stock option expense for periods
through and including
2005 as if it had been required. 2006 numbers include the effect of stock option expense.
1. Thermo is leading the way
Size matters!
World-class technologies
Scientific instruments leader
Laboratory equipment powerhouse
Integrated solutions for the lab
Integrated workflow solutions
Beyond the Box informatics & services
Instruments solutions outside the lab
Strong industrial & laboratory demand
fueling growth
2005 actual up 25% over 2004,
2006 expected to be 14-18% over 2005
2. Adjusted EPS growth is
accelerating
3. Growth platform has
momentum
4. Continued focus
on productivity
5. Balanced customer base
Practical Process Improvement (PPI)
will drive further margin and cash
flow improvement
7
The Industry is Changing
Customer Trends:
More globally dispersed
More interested in efficiency
Fewer suppliers
More accurate analysis
Integrated workflow solutions
Thermo Capabilities:
Global footprint
Largest sales & services team
Broad, but integrated, set of
technologies
Largest R&D budget
Strong balance sheet to fund
acquisitions
As the industry leader, we are in a strong position
Thermo well positioned to win
8
Thermo Today
$2.8B in revenues
1 global brand
11,000 employees
Operations in 30 countries
Headquartered near Boston, MA
S&P 500
The world leader in analytical instruments
9
The World Leader in Analytical Instruments
Our instrument solutions enable customers to make the world
a healthier, cleaner and safer place
10
Thermos Analytical Technologies
Mass Spectrometry
FT-IR Spectroscopy
Raman Spectroscopy
X-Ray Diffraction
X-Ray Fluorescence
UV-Vis Absorbance
Atomic Absorption
High-Pressure Liquid
Chromatography
Gas Chromatography
Chemiluminescence
Photochemistry
Pulsed UV Fluorescence
Inductively Coupled Plasma
World-class technologies
11
Thermos Analytical Technologies
Drug Discovery
Forensic Science
Clinical Diagnostics
Environmental Testing
Safety & Security
Quality Control
Advanced technologies tackling tough analytical challenges
12
External Recognition
IBO 2005 Company of the Year
2005 Frost & Sullivan Award:
LIMS Market Leader
2006 Pittcon
Editors Gold Award
13
Two Segments
Pharma/biotech labs
Clinical labs
Government/university labs
Industrial labs
Forensics labs
Environmental labs
MEASUREMENT & CONTROL
25%
Safety and security
Air/water quality
Safety & security
In-line manufacturing processes
Pharmaceuticals production
Food/beverage processing
Chemicals/materials production
THERMO OUTSIDE THE LAB
LIFE & LABORATORY SCIENCES
75%
THERMO INSIDE THE LAB
14
Business Landscape
Outstanding portfolio mix
15
Diverse Markets & Geographic Spread
North America
Asia
Other
Europe
Geographic
Distribution
Globally positioned
Environmental/
Security
Clinical
Industrial
Pharma/Biotech
Academia/Govt.
End
Markets
Balanced customer base
16
VC Funding Flow into Biotech
Stronger equity flow into biotech driving laboratory investment
Billions
Equity Raised By Biotech*
*Source: Thomas Weisel Partners LLC
17
Big Pharmas Investment in R&D
Top 10 Survey R&D Spend Trend*
*Source: Pharmaceutical Executive Magazine: Top 50 Survey Reports **Assumes 4% growth in Top 10 Pharma R&D spend for 2006
Billions
Growth continues albeit at a slower rate
18
Private Sector Fueling Research
Private research grants on the rise
Source: www.bcm.edu
19
Commodity Pricing & Industrial Capacity Utilization
*Steel data illustrates an average of three indices
*
Upward Price Trend
Tightening Capacity Trend
Industrial customers continue to invest in capacity expansion
April industrial capacity utilization
rose to 81.9% from 81.4% in March
Last month's utilization rate was the
highest since July 2000 and rose to
about one percentage
point above
the 1972-2005 average, according
to the Fed.
Source: Dow Jones May 2006
20
Thermos Competitive Position
Fisher Scientific
Sigma Aldrich
Invitrogen
Varian
PerkinElmer
Mettler Toledo
Waters
GE Healthcare
Beckman Coulter
Agilent
Technologies
Applied
Biosystems
Thermo
Company
21
Two Growth Drivers Unique to Thermo
1.
Total integrated instruments solutions for the laboratory
Designed workflows for Sample Preparation, Analysis, Data Interpretation,
Automation, and Services
Examples:
Biomarker Proteins
2.
Take laboratory analytical technologies outside the laboratory
Process control instrumentation
Environmental monitoring instrumentation
Safety and security instrumentation
Drives our new product and acquisition strategy
22
Enabling Integrated Workflows in the Lab
Thermo uniquely positioned
Laboratory Equipment
Scientific Instruments
Informatics & Services
Laboratory Services
Automation
Consumables/Reagents
Sample
Preparation
Sample
Analysis
Data
Interpretation
& Storage
CRS Robotics
Innaphase
USCS, LMSi
Jouan, Kendro
Ionalytics
23
Robotics
Centrifuges
Concentrators
Liquid
Chromatography/
Mass Spectrometry
Lab
Information
Management
System
Microplate
Readers
Software
Xcalibur
Protein
Fractionation
Enabling Integrated Workflows in the Lab:
Biomarker Research
Freezers
Data
Interpretation
& Storage
Sample
Preparation
Sample
Analysis
Cells or
Tissue
Biomarker
Identification
24
Lab to Line Strategy
Taking Instruments Outside the Lab
From Recipe Measurements to End-Point Detection
Increased Regulatory Pressures
Economics & Profitability
Protection from Liabilities
Key Drivers:
25
Applications
Technology in
the Laboratory
Fermentation Analysis
Protein & Vaccine Production
Mass Spectrometry
Tablet Inspection
FTIR Imaging Systems
FTIR & NIR
Lab to Line Opportunities
Alloy Formulation
Steel and Metals Production
X-ray Fluorescence
Sulfur Analysis in Gasoline
Pulsed UV Fluorescence
Refinery Operations
We have already demonstrated key successes with
leading customers in the process industries
Migration
to Process
Can Filling
Food/Beverage Inspection
X-Ray Imaging
Coal Blending
Coal Production
Gamma Radiation Imaging
26
Acquisitions & Divestitures since March 2005
Significantly stronger portfolio
Niton - Portable X-Ray Instruments
R&P - Air Quality Instruments
Kendro - Laboratory Equipment
Ionalytics FAIMS for Mass Spectometry
Omega Data Systems Instrument Software
Biostar Point of Care
Allen Coding
Acquisitions
Divestitures
Total Cost $937M
Revenue $425M
Total Proceeds $64M
Revenue $43M
Total:
Total:
27
Financial Goals
Revenue
Driving adjusted EPS growth to 19% CAGR
Goal
Adjusted EPS
$2.81 - $2.86
Billions
Goal
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in Appendix A,
which is also available on the companys
website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1 2006. Adjusted items also include pro-forma stock option expense for
periods through and including
2005 as if it had been required. 2006 numbers include the effect of stock option expense.
28
$2.81 - $2.86B
$1.47
$350M
13.3%
$2.63B
2005
Actual
$1.68 - $1.73
$420-430M
14.7-15.2%
2006
Goal
$1.18
$262M
11.9%
$2.21B
2004
Actual
14-18%
Adjusted EPS
20-23%
140-190 bps
Adjusted Operating Income
% of Revenue
7-9%
(5-6% organic
growth)
Revenue
05 VS. 06
Change
Financial Goals
Thermo positioned for a strong 2006
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in Appendix A,
which is also available on the companys
website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1 2006. Adjusted items also include pro-forma stock option expense for
periods through and including
2005 as if it had been required. 2006 numbers include the effect of stock option expense.
29
Combination of Industry Leaders
Accelerates Earnings Growth
Industry transforming
Exciting growth opportunities
World-class capabilities
Compelling financial benefits
30
Combined Financial Strength
$2.27 - $2.37
Adjusted EPS
Over $1 billion
$1.5 - $1.6 billion
17%
$9.2 - $9.3 billion
2007
Operating Cash Flow
Adjusted Operating Income
% Margin
Revenue
Note: Above items include the effect of stock option expense.
31
The World Leader in Analytical Instruments
Our instrument solutions enable customers to make the world
a healthier, cleaner and safer place
32
Thermo Electron Corporation
Building Financial Momentum
Pete Wilver
Chief Financial Officer
2006 Annual Investor Conference
May 24, 2006
Financial Update
2007 Outlook
2006 Guidance
Financial Trends
2005 Actual Results
34
Full Year 2005 Actual Results
Excellent financial performance
exceeded
high-end of original EPS guidance by $0.10
Full Year
20052004 Inc/(Dec)
Revenue $2,633 $2,206 19%
Organic Growth 4%4%
Adj. Operating Income $350 $262 34%
% of Revenue 13.3% 11.9% 1.4%
Free Cash Flow $245 $206 19%
Adjusted EPS $1.47 $1.18 25%
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in Appendix A
which is also available on the companys website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1 2006. Adjusted
items also include pro-forma stock option expense
for periods through and including 2005 as if it had been required.
35
Revenue Trend
$ Billions
Reported Growth
Organic Growth
3%
4%
(3%)
16%
19%
4%
79%
56%
$1.90
$2.21
$2.63
$2.812.86
36
Adjusted Operating Income Trend
$ Millions
YOY Growth
% of Sales
11%
11.9%
11.4%
21%
34%
13.3%
2023%
14.715.2%
$216
$262
$350
$420430
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in Appendix A
which is also available on the companys website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1 2006. Adjusted items
also include pro-forma stock option expense
for periods through and including 2005 as if it had been required. 2006 numbers include the effect of stock option expense.
37
Adjusted EPS Trend
YOY Growth
14%
18%
25%
1418%
$1.00
$1.18
$1.47
$1.681.73
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in Appendix A,
which is also available on the companys website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1 2006. Adjusted items
also include pro-forma stock option
expense for periods through and including 2005 as if it had been required. 2006 numbers include the effect of stock option expense.
38
Free Cash Flow Trend
$ Millions
$163
$206
$245
$275300
YOY Growth
97%
26%
19%
1222%
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in Appendix A,
which is also available on the companys website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1 2006.
39
Q1 2006 Actual Results
Last four quarters average 7% organic growth, 200+ bps
margin expansion and over 25% adjusted EPS growth
First Quarter
($ in millions, except EPS)
20062005 Inc/(Dec)
Revenue $684 $559 22%
Organic Growth 10% 0%
Adj. Operating Income $97 $61 58%
% of Revenue 14.2% 11.0% 3.2%
Adjusted EPS $0.39 $0.29 34%
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in Appendix A,
which is also available on the companys website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1 2006. Adjusted items
also include pro-forma stock option expense
for periods through and including 2005 as if it had been required. 2006 numbers include the effect of stock option expense.
40
14-18%
$1.47
$1.68-1.73
Adjusted EPS
$245
$350M
13.3%
$2.63B
4%
2005
Actual
12-22%
$275-300M
Free Cash Flow
20-23%
140-190 bps
$420-430M
14.7-15.2%
Adj. Operating Income
% of Revenue
7-9%
$2.81-2.86B
5-6%
Revenue
Organic Growth
YOY
Change
2006
Goal
2006 Financial Goals
Continuing financial momentum in 2006
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in Appendix A,
which is also available on the companys website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1 2006. Adjusted items
also include pro-forma stock option expense
for periods through and including 2005 as if it had been required. 2006 numbers include the effect of stock option expense.
41
2005-2006 Adjusted EPS Bridge
2006
Guidance
2005
Actual
Inflation
Below
the Line
Productivity
Balanced contribution from growth and productivity
Revenue
Growth
$1.47
($0.24)
($0.08)
$0.32-0.36
$0.20-0.22
$1.68-1.73
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in Appendix A,
which is also available on the companys website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1 2006. Adjusted items
also include pro-forma stock option expense
for periods through and including 2005 as if it had been required. 2006 numbers include the effect of stock option expense.
42
Balance Sheet Leverage
Ample room to make additional cash acquisitions
1.3X
16%
$2,874
($249)
$560
$311
Q1 2006
($304)
$271
Net Cash (Debt)
18%
8%
Total Debt/Capitalization
1.5X
0.8X
Total Debt/Adjusted EBITDA (LTM)*
Leverage
$2,793
$2,666
Shareholders Equity
$599
$241
Total Debt
$295
$512
Total Cash & Equivalents
2005
2004
($ in millions)
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in Appendix A,
which is also available on the companys website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1 2006. Adjusted items
also include pro-forma stock option expense
for periods through and including 2005 as if it had been required. 2006 numbers include the effect of stock option expense.
*Adjusted EBITDA equals adjusted operating income excluding depreciation.
43
2007 Outlook (Thermo Fisher Scientific)
$2.27-2.37
34-38%
Adjusted EPS
YOY Growth
Over $1B
$1.5-1.6B
17%
$9.2-9.3B
2007
Operating Cash Flow
Adjusted Operating Income
% of Revenue
Revenue
Exceptional adjusted EPS growth
and compelling cash flow
Note: Above items include the effect of stock option expense.
44
Longer-term Financial Goals
(Thermo Fisher Scientific)
18-20%
Adjusted EPS Growth
19-20%
6-8%
Adjusted Operating Margin
Organic Revenue Growth
Tremendous upside for shareholders
Note: Above items include the effect of stock option expense.
45
Driving Margin Improvement
Marc N. Casper
Senior Vice President
2006 Annual Investor Conference
May 24, 2006
Driving Margin Improvement
Goal: Continue to expand adjusted operating margins
by approximately 150 basis points per annum
Adjusted
Operating Margins
Adjusted Operating Margin
Expansion Last 4 Quarters
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in
Appendix
A, which is also available on the companys website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1
2006. Adjusted items also include pro-forma stock option expense
for periods through and including 2005 as if it had been required. 2006 numbers include the
effect of stock option expense.
14.7
15.2%
47
~150 basis
points
margin
expansion
per year
Driving Margin Improvement
Volume
Leverage
Price
Productivity
Acquisition
Integration
0
150
48
Driving Margin Improvement
Driving organic growth
- Vitality Index & new products
- Leading commercial capabilities
- Attractive customer base
Price
PPI driving productivity
Acquisition integrations
- Niton
- Kendro
49
Driving Organic Growth:
Vitality & New Products
New products are a key growth driver
LTQ Orbitrap
Mass Spec
15%
20%
23%
Vitality Index
25%
Darwin LIMS
Software
iCAP 6500
Pittcon
Gold
2006
Sorvall RC6
NITON
Analyzer
Mercury
Freedom
System
Percent
Percent of product revenue from new
products introduced in the last two
years
$160 million R&D investment
50
Worldwide presence
Direct & indirect
channels
Services
Powerful combination driving accelerated growth!
Driving Organic Growth:
Leading Commercial Capabilities
4,000 Employees Working With Customers Every Day
Global Reach
Team Selling
Key accounts
Product &
applications
specialists
Educating customers
Extended lab services
Asset management
51
Driving Organic Growth:
Leading Commercial Capabilities
World-Class Customer Demo Centers
Paris
London
West Palm Beach, FL
Tokyo
Frankfurt
Somerset, NJ
Shanghai
Bremen
San Jose, CA
Mumbai
Breda
Madison, WI
52
Driving Organic Growth:
Shanghai Customer Demo Center
Shanghai Demo Center
Working Demo Labs for all product lines
Thermo China headquarters
Shanghai sales office
40,000 square feet
53
Driving Organic Growth:
Attractive Customer Segments
Drug Discovery
Forensic Science
Clinical Diagnostics
Environmental Testing
Safety & Security
Quality Control
Advanced technologies tackling
tough analytical challenges
54
Driving Organic Growth:
At Work With Our Customers
Searching for therapies for
cancer, diabetes, & mental illness
Broad Institute
Research collaboration of MIT & Harvard
230,000 sq/ft laboratory facility
Early engagement with Thermo
Provided a suite of equipment &
instruments, including
- Thermal cyclers
- Centrifuges
- Incubators
- Reagent dispensers
- LTQ FT mass spectrometer
- LTQ Orbitrap mass spectrometer
55
a program that not
only saves us money,
but simultaneously
improves the quality of
our service.
Ed Dondero, Biogen Idec
Director of Facilities
Optimizing Laboratory Assets
Driving Organic Growth:
At Work With Our Customers
Customer Challenge
Reduce equipment maintenance costs:
1,000 instruments from 70 different vendors
Consolidate $1 million+ in service contracts
Obtain an accurate asset inventory
Maintain existing quality of service
Results
4 year savings of $1.3M
Annual savings >15%
Reduced administrative burden
Redeployment of idle assets
56
Driving Margin Improvement
Driving organic growth
- Vitality Index & new products
- Leading commercial capabilities
- Attractive customer base
Price
PPI driving productivity
Acquisition integrations
- Niton
- Kendro
57
Driving Margin Improvement :
Pricing Discipline at Thermo
PPI best practice sharing
Incentive compensation
alignment at all levels
Discount approval authority
Training
Quick market intelligence
Thermo Implementation
Continuous learning
Reward success
Execution discipline
Positioning our solutions
Competitive dynamics
Focus
58
Driving Margin Improvement:
Productivity - Practical Process Improvement
Wireless
Communication
Cross-company team
$500k savings
$30M impact per year from PPI
Customer Order
Acknowledgement
Compliance test
business unit
Process reduced from
17 days to 12 minutes
Lean Keys in
Asheville Factory
$10M inventory reduction
$2M lower labor cost
PPI continuous-improvement methodology utilized by Thermo
4500 employees trained, 40% of work force
Delivers 2-3% savings impact per annum
Representative teams:
59
Driving Margin Improvement:
Productivity - Sourcing
Levers
Annual Sourcing
Savings
Components Sourced
from Low-Cost Region
$ Sourced Components
$ Savings Target
$ Millions
$ Millions
Supplier negotiation
Spend aggregation
Alternate source
Value engineering
Make vs. Buy
Low-cost region sourcing
60
Driving Margin Improvement:
Productivity From Low Cost Region Production
30 - 35% cost-reduction opportunity
leveraging China capabilities
*Assumes 40% COGS at 35% savings
China: Annual Production Run Rate
$ China Production
$ Savings Target
$ Millions
61
Driving Margin Improvement
Driving organic growth
- Vitality Index & new
products
- Leading commercial
capabilities
- Attractive customer base
Price
PPI driving productivity
Acquisition integrations
- Niton
- Kendro
62
Driving Margin Improvement:
Acquisition Integration
Supports growing demand for
field applications
First-line RoHS screening
Simple point & shoot operation
Acquired March 2005
Handheld elemental X-Ray
analysis
$36M revenue in 2004:
12% adjusted operating margin
$65M revenue last 4 quarters:
19% adjusted operating margin*
NITON Case Study
Enabling RoHS Compliance
**RoHS Restriction of Hazardous Substances
*13% on a GAAP basis, including 6% of amortization of acquired intangibles
**
63
Driving Margin Improvement:
Acquisition Integration
$833M acquisition
$365M revenue
Closed May 2005
Extends key lines of
lab equipment
Sorvall, Heraeus, Revco
Kendro Case Study
64
Driving Margin Improvement:
Acquisition Integration
Plan
Status / Accomplishments
Powerful world-scale lab-equipment platform to deliver
accelerated growth and margin expansion
Increased resources to bring
solutions to our major-market customers
Integrated commercial organization
& offices with one face to customer
Created new R&D centers of
excellence to leverage expertise
& accelerate product vitality
PPI fully introduced employees
trained and driving rapid
operating improvements
Headcount reduced by 200
4 manufacturing sites consolidated
Rapid integration of all functions,
processes & product lines within
one clear organization
Technology excellence
Productivity
Operations & business
integration
Key account focus
Commercial integration
Kendro Case Study Results One Year Later
65
Driving Margin Improvement:
Acquisition Integration
Achieved
Exceeded 10¢ accretion in
first 12 months
10¢ accretive to adjusted EPS
in first full year
On Track
Realized $12M in first 12 months
At $16M run rate
$30M synergies by year 3
Status / Accomplishments
Plan
Kendro Case Study Results One Year Later
Note: For historical periods, all items identified as adjusted as well as free cash flow are reconciled to the most directly comparable GAAP measures in
Appendix
A, which is also available on the companys website, www.thermo.com, in the Investors section under Reconciliation of Financial Information Q1
2006. Adjusted items also include pro-forma stock option expense
for periods through and including 2005 as if it had been required. 2006 numbers include the
effect of stock option expense.
66
Summary
Note: Above items include the effect of stock option expense.
Thermo delivering significant expansion of adjusted
operating margins
Continue ~150 point margin expansion per annum
Margin expansion driven by:
- Volume leverage from organic growth
- Price
- Productivity initiatives
- Acquisition integration impact
67
New Product Momentum
Ian D. Jardine Ph.D.
Vice President Global R&D
2006 Annual Investor Conference
May 24, 2006
Celebrating 50 Years of Innovation
Early Emissions
Testing Technology
Leading-edge Mercury
Emissions Monitoring
Early Mechanical
Heart Development
Advanced
Biomarker Research
Then
Now
Continually enabling the
advancement of science
George N. Hatsopoulos
Thermo Electron founder
69
New Product Momentum
Thermo is recognized as innovation leader
15%
20%
23%
25%
Vitality Index
Percent
Percent of product revenue from new products
introduced in the last 2 years
$160 million R&D Investment
70
Continually Launching High Impact Products
Off-the-shelf
LIMS Solution
Award Winning
Innovation
Breakthrough
Sensitivity
Darwin LIMS
LTQ Orbitrap
iCAP Series
Informatics
Mass Spectrometry
Elemental Analysis
$200 Million
Market
$200 Million
Hybrid Market
$250 Million
Market
TM
TM
TM
71
Winning LIMS Solution
For pharmaceutical quality control & R&D
Off-the-shelf LIMS with complete range of
standard features reduces total cost of ownership
Enables rapid deployment across multiple sites
with resulting large productivity gains
Powerful new LIMS solution to grow our leading market share
DARWIN Laboratory Information Management System (LIMS)
$250
Million
Market
DARWIN
LIMS
TM
72
Next Generation Elemental Analyzer
Innovative optics & breakthrough camera technology
delivers the highest performance in the smallest footprint
iCAP 6000 Series ICP-OE Elemental Analyzer
CID86
Camera
$200 Million
Market
TM
TM
Delivers up to 5X gain in performance
- Improved sensitivity for key
environmental elements such as Arsenic and
Selenium
Dramatically cuts purge gas consumption
- Saves $ thousands in annual operating
costs
Compact and easy to use
- Improves lab productivity
73
LTQ Orbitrap Hybrid Mass Spectrometer
Mass Spectrometry Breakthrough
Phenomenal customer reception!
$200 Million
Hybrid Market
TM
Mass Spectrometers
- Detect and
conclusively identify
compounds very accurately and at very
high sensitivity
First completely NEW mass spectrometer
analyzer in more than 20 years
- Ideal for small-molecule (e.g. drugs)
and peptide/protein identification and
quantitation
Orbitrap is 5X TOF in performance
- Resolution, mass accuracy, sensitivity,
speed, and dynamic range
74
Enabling Customers
Dr. Steven Carr, BROAD Institute
MIT/Harvard Labs, Cambridge MA
Proteomics & Biomarker Discovery
Video Interview
75
Sample
Preparation
New Product Momentum:
Pittcon Introductions March 06
Services
Sample
Analysis
iCAP ICP-OE
NIR analyzers
Detectors for
Surveyor
Plus LC
DFS High-res
GC-MS
LTQ Orbitrap
mass spectrometer
Finnigan LXQ
mass spec
Evolution 600 UV-Vis
Spectrophotometer
NITON
elemental
analyzers
LIFECYCLE Asset Management
Biorepository Services
Data
Interpretation
& Storage
Sorvall RC6 Plus
Super-speed
centrifuge
Novus
Finnpipette
Espresso
Personal
centrifuge
Sample Manager
NET & COTS
Darwin LIMS
OMNIC 7.3
QuickQuan
Navigator
AA iSQ
module
Appliskan
multimode
microplate
reader
NESLAB
ThermoFlex
temperature
control
HAAKE
DynaMax
temperature
control
76
HPLC: Separation - Detection - Quantitation
Solvent
reservoir
Pump
Injector
Column
UV or Mass
Spectrometer
Detector
Data
recorder
1. Inject sample mixture
2. Separate into individual components
3. Detect and report
HPLC Hardware Market >$1 Billion
Columns Market >$0.5 Billion
MS Market for HPLC >$1 Billion
77
Introducing: Accela High Speed UHPLC
More flexibility than any competitive system!
Challenge: Demand for Faster Chromatography
Launching at American Society for
Mass Spectrometry Conference &
Exhibit in Seattle starting May 28th
TM
Fastest HPLC/UHPLC
- Unique pump and system design
Two HPLC systems in one
- Designed to run at conventional
(5,000 psi)
and very high pressures
(15,000 psi)
Hypersil Gold 1.9 mm column
- Superb peak symmetry and resolution
78
Column:
A. 150 x 4.6 mm 5.0 um C18
Hypersil Gold
B. 50 x 2.1 mm 1.9 u
m C18
Hypersil Gold
Flow rate: A. 1000 ul/min
B. 700 u
l/mi
Pressure: A. 155 bar
B. 380 bar
Detection: LTQ Orbitrap
Resolution : 30,000
Analytes -Steroids
1. Testosterone
2. 19-Nortestosterone
3. 17- -Methyltestosterone
4. 1-Dehydrotestosterone
Accela UHPLC + Hypersil Column + Orbitrap MS
0
2
4
6
8
10
12
14
Time (min)
0
10
20
30
40
50
60
70
80
90
100
Conventional
12 Minutes
High Speed
2 Minutes
1
1
2
3
4
2
3
4
TM
79
Even More Performance
FAIMS Triple Quad
LTQ FT
Ultra
TSQ QUANTUM
with FAIMS
Environmental Triple Quad
New Linear Ion Trap
TSQ Quantum Access
LTQ XL with ETD
American Society for Mass Spectrometry
Conference and Exhibit - New Product Preview
Seattle
May 28th
to
June 2nd
TM
TM
TM
TM
80
Customer Recognition for Mass Spec Excellence
Great customer feedback
Thermo
Thermo
Ease-of-Use
Thermo
Applied Biosystems
Technical Specs
2005 Top Supplier
2004 Top Supplier
Category
Thermo
Thermo
Waters
Thermo
Thermo
Instrument Reliability
Thermo
Customer Service
Waters
Software & Data Handling
Thermo
Price/Value
Source: ASMS 04 & 05 Surveys
American Society of Mass Spectrometry Survey
81
Introducing: Powerful New Software at ASMS
QuickQuan
MALDI Tissue Imaging
Top Down Proteomics
Automated LC-MS/MS
Drug Discovery
Biomarker Differential Analysis
Auto MSn Structural Analysis
High Resolution/Accurate Mass
TM
82
Proteomics Global Protein Identification
Lysate
Protein fractionation
Protein depletion
Protease digestion
Peptide selection
Peptide separation
Protein mixture
Peptide mixture
Peptides
for MS/MS
Cells or Tissue
Cellular
fractionation
Protein Identification
83
Controls
Disease or
Treated
Automatically compares all LC-MS/MS data
in
disease/treated versus controls
Picks out and identifies those proteins which
have increased or decreased in concentration
SIEVE - Global Differential Analysis Software
Controls
Disease or
Treated
LC-MS/MS
84
SIEVE Auto Differential Expression Software
Gigabyte Data Sets of
High Resolution/
Accurate Mass
LC-MS/MS Information
Time
MS/MS
Mass
Intensity
Multi-experiment
Quantitation of
Thousands of
Specific Proteins
Automating the process of biomarker discovery
Months of data analysis in minutes!
85
A Bright Future:
Enabling Integrated Lab Workflow Solutions
Data
Interpretation
& Storage
Sample
Preparation
Sample
Analysis
Complementary
Reagents & Consumables
Xcalibur
Proteomics Research Application
Cells or
Tissue
Biomarker
Identified
Or Measured
Fisher
Thermo
86
Cellular Protein Network Mapping Workflow
Cellular Location
by Color
Protein Interactions are the basis for
almost all cellular activity
Understanding of Interaction Pathways in
Networks illuminates:
- Cell Division (Growth)
- Cell Differentiation (Stem Cells)
- All Cancers
- Immunity
- Metabolic Disease
- Inflammatory Disease
- Biomarkers of Disease
- Drug Action
and much more
87
Cellular Protein Network Mapping Workflow
Key: Blue = Fisher
Red = Thermo
88
Cellular Protein Network Mapping Workflow
Key: Blue = Fisher
Red = Thermo
89
Cellular Protein Network Mapping Workflow
Key: Blue = Fisher
Red = Thermo
90
Cellular Protein Network Mapping Workflow
*
*
*
*
*
Key: Blue = Fisher
Red = Thermo
91
Summary
Unparalleled track record of innovation
2006 another milestone year
Future is even brighter as Thermo Fisher Scientific
92