FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * Abingworth Management LTD   2. Issuer Name and Ticker or Trading Symbol Solexa, Inc. [SLXA] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 38 JERMYN STREET 3. Date of Earliest Transaction (Month/Day/Year) 01/27/2006 (Street) LONDON, X0 SW1Y 6DN 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 01/27/2005   J(1)   849,998 D $ 0 1,416,438 I See Footnote (2) Common Stock 01/27/2006   J(3)   229,999 D $ 0 383,279 I See Footnote (4) Common Stock 01/27/2006   J(5)   461,838 D $ 0 764,931 I See Footnote (6) Common Stock 01/27/2006   J(7)   281,932 D $ 0 466,937 I See Footnote (8) Common Stock 01/27/2006   J(9)   168,878 D $ 0 279,700 I See Footnote (10) Common Stock 01/27/2006   J(11)   7,355 D $ 0 12,195 I See Footnote (12)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Abingworth Management LTD 38 JERMYN STREET LONDON, X0 SW1Y 6DN		X

Signatures

James Abell, Director of Abingworth Management LTD		01/31/2006
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	On January 27, 2006, Abingworth BioVentures II S.I.C.A.V. distributed an aggregate of 849,998 of the Issuer's Common Stock to its shareholders for no consideration.
(2)	These shares are owned directly by Abingworth BioVentures II S.I.C.A.V., of which Abingworth Management LTD is the manager. Abingworth Management LTD disclaims beneficial ownership of the securities held by Abingworth BioVentures II S.I.C.A.V., except to the extent of its pecuniary interest therein.
(3)	On January 27, 2006, Abingworth BioVentures II A L.P. distributed an aggregate of 229,999 of the Issuer's Common Stock to its partners for no consideration.
(4)	These shares are owned directly by Abingworth BioVentures II A L.P., of which Abingworth Management LTD is the manager. Abingworth Management LTD disclaims beneficial ownership of the securities held by Abingworth BioVentures II A L.P., except to the extent of its pecuniary interest therein.
(5)	On January 27, 2006, Abingworth BioVentures III A L.P.distributed an aggregate of 461,838 of the Issuer's Common Stock to its partners for no consideration.
(6)	These shares are owned directly by Abingworth BioVentures III A L.P., of which Abingworth Management LTD is the manager. Abingworth Management LTD disclaims beneficial ownership of the securities held by Abingworth VioVentures III A L.P., except to the extent of its pecuniary interest therein.
(7)	On January 27, 2006, Abingworth BioVentures III B distributed an aggregate of 281,932 of the Issuer's Common Stock to its partners for no consideration.
(8)	These shares are owned directly by Abingworth BioVentures III B L.P., of which Abingworth Management LTD is the manager. Abingworth Management LTD disclaims beneficial ownership of the securities held by Abingworth BioVentures III B L.P., except to the extent of its pecuniary interest therein.
(9)	On January 27, 2006, Abingworth BioVentures III C distributed an aggregate of 168,878 of the Issuer's Common Stock to its partners for no consideration.
(10)	These shares are owned directly by Abingworth BioVentures III C L.P., of which Abingworth Management LTD is the manager. Abingworth Management LTD disclaims beneficial ownership of the securities held by Abingworth BioVentures III C L.P., except to the extent of its pecuniary interest therein.
(11)	On January 27, 2006, Abingworth BioVentures III Executives distributed an aggregate of 7,355 of the Issuer's Common Stock to its partners for no consideration.
(12)	These shares are owned directly by Abingworth BioVentures III Executives L.P., of which Abingworth Management LTD is the manager. Abingworth Management LTD disclaims beneficial ownership of the securities held by Abingworth BioVentures III Executives L.P., except to the extent of its pecuniary interest therein.

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