SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934

                               (Amendment No. 22)*

                            ISCO International, Inc.
                                (Name of Issuer)

                          Common Stock, par value $.001
                         (Title of Class of Securities)

                                    46426P103
                                 (CUSIP Number)

                            Stephen M. Schultz, Esq.
                    Kleinberg, Kaplan, Wolff & Cohen, P.C.,
                   551 Fifth Avenue, New York, New York 10176
                              Tel: (212) 986-6000
                 (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)

                                 August 2, 2005
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box
[ ].

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including  all  exhibits.  See Rule 13d-7(b) for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                  Elliott Associates, L.P.

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
         (a)[x]
         (b)[ ]

3.       SEC USE ONLY

4.       SOURCE OF FUNDS*
                  WC

5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
         REQUIRED PURSUANT TO ITEMS 2(d) or 2(e) [  ]

6.       CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

7.       SOLE VOTING POWER
                  15,357,168

8        SHARED VOTING POWER
                  0

9.       SOLE DISPOSITIVE POWER
                  15,357,168

10.      SHARED DISPOSITIVE POWER
                  0

11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  15,357,168

12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
         EXCLUDES CERTAIN SHARES*   [ ]

13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  8.4%

14.      TYPE OF REPORTING PERSON*
                  PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                  Elliott International, L.P.

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
         (a)[x]
         (b)[ ]

3.       SEC USE ONLY

4.       SOURCE OF FUNDS*
                  WC

5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
         REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     [  ]

6.       CITIZENSHIP OR PLACE OF ORGANIZATION
                  Cayman Islands, British West Indies

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

7.       SOLE VOTING POWER
                  0

8.       SHARED VOTING POWER
                  19,904,159

9.       SOLE DISPOSITIVE POWER
                  0

10.      SHARED DISPOSITIVE POWER
                  19,904,159

11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
         REPORTING PERSON
                  19,904,159

12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
         EXCLUDES CERTAIN SHARES*           [ ]

13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  10.9%

14.      TYPE OF REPORTING PERSON*
                  PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                  Elliott International Capital Advisors, Inc.

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
         (a)[x]
         (b)[ ]

3.       SEC USE ONLY

4.       SOURCE OF FUNDS*
                  00

5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
         REQUIRED PURSUANT TO ITEMS 2(d) or 2(e) [  ]

6.       CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH
REPORTING PERSON WITH

7.       SOLE VOTING POWER
                  0

8.       SHARED VOTING POWER
                  19,904,159

9.       SOLE DISPOSITIVE POWER
                  0

10.      SHARED DISPOSITIVE POWER
                  19,904,159

11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
         REPORTING PERSON
                  19,904,159

12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
         EXCLUDES CERTAIN SHARES*           [ ]

13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  10.9%

14.      TYPE OF REPORTING PERSON*
                  CO

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



     This  statement is filed with respect to the shares of common stock,  $.001
par value  (the  "Common  Stock") of ISCO  International,  Inc.  (the  "Issuer")
beneficially owned by Elliott Associates, L.P. and its wholly-owned subsidiaries
(collectively, "Elliott"), Elliott International, L.P. ("Elliott International")
and Elliott  International  Capital Advisors,  Inc.  ("EICA")(collectively,  the
"Reporting  Persons")  as of August  9,  2005 and  amends  and  supplements  the
Schedule 13D dated April 7, 1999, as previously  amended (the  "Schedule  13D").
Except  as set forth  herein,  the  Schedule  13D,  as  previously  amended,  is
unmodified.

ITEM 2.  Identity and Background.

     (a)-(c)  This  statement  is being  filed by Elliott  Associates,  L.P.,  a
Delaware limited partnership,  and its wholly-owned subsidiaries  (collectively,
"Elliott"),  Elliott  International,  L.P., a Cayman Islands limited partnership
("Elliott  International"),  and Elliott  International Capital Advisors Inc., a
Delaware   corporation   ("EICA"  and  collectively  with  Elliott  and  Elliott
International,  the "Reporting  Persons").  Paul E. Singer  ("Singer"),  Elliott
Capital Advisors,  L.P., a Delaware limited  partnership  ("Capital  Advisors"),
which is controlled by Singer,  and Elliott  Special GP, LLC ("Special GP"), are
the general partners of Elliott.  Hambledon,  Inc., a Cayman Islands corporation
("Hambledon"),  which is also controlled by Singer,  is the sole general partner
of  Elliott   International.   EICA  is  the  investment   manager  for  Elliott
International.  EICA expressly  disclaims  equitable  ownership of and pecuniary
interest in any shares of Common Stock.

     ELLIOTT

     The business address of Elliott is 712 Fifth Avenue,  36th Floor, New York,
New York 10019.

     The principal business of Elliott is to purchase, sell, trade and invest in
securities.

     SINGER

     Singer's  business  address is 712 Fifth Avenue,  36th Floor, New York, New
York 10019.

     Singer's principal business is to serve as a general partner of Elliott and
Capital Advisors,  as the president of EICA, and as a managing member of Special
GP.

     CAPITAL ADVISORS

     The business address of Capital  Advisors is 712 Fifth Avenue,  36th Floor,
New York, New York 10019.

     The principal  business of Capital Advisors is the furnishing of investment
advisory services.  Capital Advisors also serves as a managing member of Special
GP.



     The  names,  business  addresses,   and  present  principal  occupation  or
employment of the general partners of Capital Advisors are as follows:

NAME                         ADDRESS                       OCCUPATION
Paul E. Singer               712 Fifth Avenue         General partner of Elliott
                             36th Floor               and Capital Advisors;
                             New York, New York 10019 President of EICA; and a
                                                      managing member of Special
                                                      GP

Braxton Associates, Inc.     712 Fifth Avenue         The principal business of
                             36th Floor               Braxton Associates, Inc.
                             New York, New York 10019 is serving as general
                                                      partner of Capital
                                                      Advisors

Elliott Asset Management LLC 712 Fifth Avenue         General Partner of Capital
                             36th Floor               Advisors
                             New York, New York 10019

     The name, business address,  and present principal occupation or employment
of the sole director and executive  officer of Braxton  Associates,  Inc. are as
follows:

     NAME               ADDRESS                       OCCUPATION
Paul E. Singer          712 Fifth Avenue              General partner of Elliott
                        36th Floor                    and Capital Advisors and
                        New York, New York  10019     President of EICA

     ELLIOTT SPECIAL GP, LLC

     The business  address of Special GP is 712 Fifth  Avenue,  36th Floor,  New
York, New York 10019.

     The  principal  business  of Special GP is serving as a general  partner of
Elliott.

     The names, business address, and present principal occupation or employment
of the managing members of Special GP are as follows:

NAME                         ADDRESS                       OCCUPATION
Paul E. Singer               712 Fifth Avenue         General partner of Elliott
                             36th Floor               and Capital Advisors;
                             New York, New York 10019 President of EICA; and a
                                                      managing member of Special
                                                      GP

Braxton Associates, Inc.     712 Fifth Avenue         The principal business of
                             36th Floor               Braxton Associates, Inc.
                             New York, New York 10019 is serving as general
                                                      partner of Capital
                                                      Advisors

Elliott Asset Management LLC 712 Fifth Avenue         General Partner of Capital
                             36th Floor               Advisors
                             New York, New York 10019


     ELLIOTT INTERNATIONAL

     The business  address of Elliott  International  is c/o c/o Bank of Bermuda
(Cayman)  Limited,  Strathvale  House,  North Church Street,  George Town, Grand
Cayman, Cayman Islands, B.W.I.

     The principal business of Elliott International is to purchase, sell, trade
and invest in securities.

     The name, business address,  and present principal occupation or employment
of the general partner of Elliott International is as follows:

NAME                    ADDRESS                       OCCUPATION
Hambledon, Inc.         c/o Midland Bank Trust        General partner of Elliott
                        Corporation (Cayman) Limited  International
                        P.O. Box 1109
                        Mary Street
                        Grand Cayman
                        Cayman Islands



     HAMBLEDON

     The name, business address,  and present principal occupation or employment
of the sole director and executive officer of Hambledon are as follows:

     NAME              ADDRESS                      OCCUPATION
Paul E. Singer         712 Fifth Avenue             General partner of Elliott
                       36th Floor                   and Capital Advisors;
                       New York, New York  10019    President of EICA; and a
                                                    managing member of Special
                                                    GP

     EICA

     The business address of EICA is 712 Fifth Avenue, 36th Floor, New York, New
York 10019.

     The principal  business of EICA is to act as investment manager for Elliott
International.

     The name, business address,  and present principal occupation or employment
of the sole director and executive officer of EICA is as follows:

     NAME              ADDRESS                      OCCUPATION
Paul E. Singer         712 Fifth Avenue             General partner of Elliott
                       36th Floor                   and Capital Advisors;
                       New York, New York  10019    President of EICA; and a
                                                    managing member of Special
                                                    GP

     (d) and (e) During the last five  years,  none of the  persons or  entities
listed above or, to the  knowledge  of such  persons or  entities,  has been (i)
convicted in a criminal  proceeding  (excluding  traffic  violations  or similar
misdemeanors);  or  (ii)  a  party  to  a  civil  proceeding  of a  judicial  or
administrative body of competent jurisdiction and as a result of such proceeding
was or is  subject  to a  judgment,  decree  or  final  order  enjoining  future
violations  of, or prohibiting  or mandating  activities  subject to, federal or
state securities laws or finding any violation with respect to such laws.

     (f) Mr. Singer is a citizen of the United States of America.

ITEM 3.  Source and Amount of Funds or Other Consideration

     The source and amount of funds used by Elliott in making its  purchases  of
the shares of Common Stock beneficially owned by it are set forth below:




SOURCE OF FUNDS                                      AMOUNT OF FUNDS
Working Capital                                      $4,667,796

     The source and amount of funds used by Elliott  International in making its
purchases of the shares of Common Stock  beneficially  owned by it are set forth
below:

SOURCE OF FUNDS                                      AMOUNT OF FUNDS
Working Capital                                      $7,515,272

ITEM 4.  Purpose of Transaction.

     Each of  Elliott  and  Elliott  International  acquired  the  Common  Stock
beneficially  owned by it in the  ordinary  course of its trade or  business  of
purchasing,  selling,  trading and  investing in  securities.  EICA has acted as
investment  manager  with  respect to  Elliott  International's  acquisition  of
beneficial ownership of Common Stock.

     Depending  upon  market  conditions  and  other  factors  that it may  deem
material,  each of Elliott and Elliott  International  may  purchase  additional
shares of Common Stock or related  securities or may dispose of all or a portion
of the Common Stock or related  securities that it now beneficially  owns or may
hereafter acquire.

     On  July  25,  2005,  Elliott  and  Elliott  International  entered  into a
Securities Purchase Agreement  ("Securities Purchase Agreement") with the Issuer
and other  parties  identified  therein,  pursuant to which  Elliott and Elliott
International  respectively  agreed to purchase  500,000 and 9,500,000 shares of
Common  Stock of the  Issuer at a purchase  price of $0.22 per share.  The above
purchases closed on August 2, 2005.

     On  July  25,  2005,   Manchester   Securities  Corp.   ("Manchester"),   a
wholly-owned  subsidiary  of Elliott,  entered  into an  Amendment to and Waiver
Under  Loan  Documents  with the Issuer and other  parties  identified  therein,
pursuant to which  Manchester  and other  lenders  agreed to extend the maturity
date of  certain  Notes  currently  outstanding  from April 1, 2006 to August 1,
2007.  Manchester  and the other  lenders  also  agreed  to waive  the  Issuer's
obligation  under a certain loan  agreement to use the proceeds from the sale of
the shares of Common  Stock  pursuant to the  Securities  Purchase  Agreement to
prepay the Notes.

     The above  agreements and their related  documents are more fully described
in the Issuer's 8-Ks filed with the Securities  and Exchange  Commission on July
26, 2005 and August 3, 2005, each of which is incorporated herein by reference.

     Except as set forth herein and as previously disclosed on the Schedule 13D,
none of Elliott,  Elliott International or EICA has any plans or proposals which
relate to or would result in any of the actions set forth in  subparagraphs  (a)
through (j) of Item 4.




ITEM 5.  Interest in Securities of the Issuer.

     (a) Elliott  beneficially  owns an aggregate of 15,357,168 shares of Common
Stock, constituting 8.4% of all of the outstanding shares of Common Stock.

     Together,  Elliott  International and EICA beneficially own an aggregate of
19,904,159 shares of Common Stock,  constituting 10.9% of all of the outstanding
shares of Common Stock.

     Elliott, Elliott International and EICA's aggregate beneficial ownership of
Common  Stock  equals  35,261,327  shares,   comprising  19.3%  of  all  of  the
outstanding shares of Common Stock.

     (b)  Elliott has the power to vote or direct the vote of, and to dispose or
direct the disposition of, the shares of Common Stock beneficially owned by it.

     Elliott  International has the shared power with EICA to vote or direct the
vote of, and to dispose or direct the disposition of, the shares of Common Stock
owned  by  Elliott   International.   Information   regarding  each  of  Elliott
International  and  EICA is set  forth  in Item 2 of  this  Schedule  13D and is
expressly incorporated herein by reference herein.

     (c) The following transaction was effected by Elliott during the past sixty
(60) days:

                                     Approx. Price per
                    Amount of Shs.   Share (excl. of
Date     Security   Bought (Sold)    commissions)      

8/2/05   Common     500,000          $0.22


     The following  transaction was effected by Elliott International during the
past sixty (60) days:

                                     Approx. Price per
                    Amount of Shs.   Share (excl. of
Date     Security   Bought (Sold)    commissions)      

8/2/05   Common     9,500,000        $0.22


     All of the above transactions were effected through a privately  negotiated
transaction with the Issuer (see Item 4 above).



     No other transactions with respect to the Common Stock that are required to
be reported and have not been previously  reported on Schedule 13D were effected
by any of the Reporting Persons during the past sixty (60) days.

     (d) No person  other than  Elliott has the right to receive or the power to
direct the receipt of  dividends  from,  or the  proceeds  from the sale of, the
shares of Common Stock beneficially owned by Elliott.

     No  person  other  than  Elliott  International  and EICA has the  right to
receive or the power to direct the receipt of  dividends  from,  or the proceeds
from the sale of,  the  shares of Common  Stock  beneficially  owned by  Elliott
International and EICA.

     (e) Not applicable.

ITEM 6.  Contracts, Arrangements, Understandings or Relationships With Respect
         to Securities of the Issuer.

     Except as otherwise described in this Schedule 13D, there are no contracts,
arrangement,  understandings or relationships  with respect to securities of the
Issuer.



                                   SIGNATURES

     After reasonable  inquiry and to the best of its knowledge and belief,  the
undersigned  each certifies that the information with respect to it set forth in
this statement is true, complete and correct.

Dated: August 10, 2005

         ELLIOTT ASSOCIATES, L.P.
         By: Elliott Capital Advisors, L.P., as General Partner
                  By: Braxton Associates, Inc., as General Partner


                      By: /s/ Elliot Greenberg
                          --------------------
                              Elliot Greenberg
                              Vice President


         ELLIOTT INTERNATIONAL, L.P.
         By:      Elliott International Capital Advisors Inc.,
                           as Attorney-in-Fact


                  By: /s/ Elliot Greenberg
                      --------------------
                          Elliot Greenberg
                          Vice President


         ELLIOTT INTERNATIONAL CAPITAL ADVISORS INC.

         By: /s/ Elliot Greenberg
             --------------------
                 Elliot Greenberg
                 Vice President