SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                    ________

                                    FORM 6-K

                        REPORT OF FOREIGN PRIVATE ISSUER
                      PURSUANT TO RULE 13a-16 OR 15d-16 OF
                       THE SECURITIES EXCHANGE ACT OF 1934

                         For the month of November, 2004

                                  Serono S.A.
                       -----------------------------------
                              (Registrant's Name)

                            15 bis, Chemin des Mines
                                 Case Postale 54
                                CH-1211 Geneva 20
                                  Switzerland
                        -------------------------------
                    (Address of Principal Executive Offices)

                                    1-15096
                       -----------------------------------
                              (Commission File No.)

     (Indicate  by  check  mark whether the registrant files or will file annual
reports under cover of Form 20-F or Form 40-F.)

     Form  20-F  X  Form  40-F
                ---            ---

     (Indicate  by  check  mark  if the registrant is submitting the Form 6-K in
paper  as  permitted  by  Regulation  S-T  Rule  101  (b)(1).)  ______

     (Indicate  by  check  mark  if the registrant is submitting the Form 6-K in
paper  as  permitted  by  Regulation  S-T  Rule  101  (b)(7).)  ______

     (Indicate  by  check  mark  whether  the  registrant  by  furnishing  the
information contained in this form is also thereby furnishing the information to
the  Commission  pursuant to Rule 12g3-2(b) under the Securities Exchange Act of
1934.)

     Yes      No  X
         ---     ---

     (If  "Yes"  is  marked,  indicate  below  the  file  number assigned to the
registrant  in  connection  with  Rule  12g3-2(b):  82-______)



                                                                          SERONO


Media  Release


FOR  IMMEDIATE  RELEASE
-----------------------



          SERONO ANNOUNCES APPOINTMENT OF NEW CHIEF FINANCIAL OFFICER



GENEVA,  SWITZERLAND  -  NOVEMBER  10, 2004 - Serono (virt-x: SEO and NYSE: SRA)
announced  today  the  appointment  of  Stuart Grant as Chief Financial Officer.
Mr  Grant  will  be  a  member of the Serono Executive Management Board and will
report  directly  to  the  CEO,  Ernesto  Bertarelli.

"Stuart  Grant  is  already  a  member of the Serono team as our Chief Financial
Officer  for  Serono  Inc.  in  the  USA."  said  Ernesto Bertarelli. "With this
appointment  we  will  benefit from his strong financial management and business
skills  at  the  overall  company  level."

Mr  Grant  has  over 25 years of financial and business management experience in
the  high  technology  sector,  in both the Corporate and Field environments. He
held  various  senior  financial  positions  with Digital Equipment Corporation,
before  joining  Serono in 1995. During his time at Serono, he has held a number
of financial and general management roles with increasing responsibility and has
demonstrated  strong  leadership.

Mr  Grant will take up his new responsibilities within the next few weeks, while
ensuring  a  smooth  transition.

Mr  Grant  graduated  with  a  Bachelor  of  Accountancy  from the University of
Glasgow,  and  is  a  Chartered  Accountant.


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                                       ###
Some  of  the  statements  in  this  press  release  are  forward  looking. Such
statements  are inherently subject to known and unknown risks, uncertainties and
other  factors  that  may  cause  actual results, performance or achievements of
Serono  S.A.  and  affiliates  to be materially different from those expected or
anticipated  in  the  forward-looking statements. Forward-looking statements are
based on Serono's current expectations and assumptions, which may be affected by
a  number  of  factors, including those discussed in this press release and more
fully  described  in  Serono's  Annual  Report  on Form 20-F filed with the U.S.
Securities  and Exchange Commission on March 25, 2004. These factors include any
failure  or  delay  in  Serono's ability to develop new products, any failure to
receive  anticipated  regulatory  approvals,  any  problems  in  commercializing
current  products  as  a  result of competition or other factors, our ability to
obtain  reimbursement  coverage  for  our  products,  and government regulations
limiting  our  ability  to  sell  our  products. Serono has no responsibility to
update the forward-looking statements contained in this press release to reflect
events or circumstances occurring after the date of this press release.
                                       ###

ABOUT  SERONO
Serono  is  a  global  biotechnology leader. The Company has eight biotechnology
products,  Rebif(R),  Gonal-F(R),  Luveris(R),  Ovidrel(R)/Ovitrelle(R),
Serostim(R),  Saizen(R),  Zorbtive(TM)  and Raptiva(R). In addition to being the
world  leader  in  reproductive  health,  Serono  has strong market positions in
neurology,  metabolism  and  growth and has recently entered the psoriasis area.
The  Company's  research programs are focused on growing these businesses and on
establishing  new  therapeutic  areas.  Currently,  there  are  approximately 30
ongoing  development  projects.

In  2003,  Serono  achieved  worldwide revenues of US$2,018.6 million, and a net
income  of  US$390.0 million, making it the third largest biotech company in the
world. Its products are sold in over 90 countries. Bearer shares of Serono S.A.,
the  holding company, are traded on the virt-x (SEO) and its American Depositary
Shares  are  traded  on  the  New  York  Stock  Exchange  (SRA).

FOR MORE INFORMATION, PLEASE CONTACT:

  CORPORATE MEDIA RELATIONS:  CORPORATE INVESTOR RELATIONS:
  Tel:  +41 22 739 36 00      Tel:  +41 22 739 36 01
  Fax:  +41 22 739 30 85      Fax:  +41 22 739 30 22
  http://www.serono.com       Reuters: SEO.VX / SRA.N
  ---------------------       Bloomberg: SEO VX / SRA US

  MEDIA RELATIONS, USA:       INVESTOR RELATIONS, USA:
  Tel:  +1 781 681 2340       Tel:  +1 781 681 2552
  Fax:  +1 781 681 2935       Fax:  +1 781 681 2912
  http://www.seronousa.com
  ------------------------



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                                   SIGNATURES

     Pursuant  to  the  requirements of the Securities Exchange Act of 1934, the
registrant  has  duly  caused  this  report  to  be  signed on its behalf by the
undersigned,  thereunto  duly  authorized.



                                   SERONO  S.A.
                                   a Swiss corporation
                                   (Registrant)



November 10, 2004                  By: /s/ Francois Naef
                                   --------------------
                                   Name: Francois Naef
                                   Title: Secretary