Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
EVNIN ANTHONY B
  2. Issuer Name and Ticker or Trading Symbol
INFINITY PHARMACEUTICALS, INC. [INFI]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O VENROCK, 530 FIFTH AVENUE, 22ND FLOOR
3. Date of Earliest Transaction (Month/Day/Year)
11/26/2012
(Street)

NEW YORK, NY 10036
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 11/26/2012   J   864,565 (1) D $ 0 311,719 I By Funds (2) (3)
Common Stock 11/26/2012   J   4,832 (4) A $ 0 316,551 I By Funds and LLC (2) (3) (4)
Common Stock 11/26/2012   J   923 (5) A $ 0 923 D  
Common Stock 11/27/2012   M   1,875 A $ 15.04 2,798 D  
Common Stock 11/27/2012   M   1,407 A $ 9.23 4,205 D  
Common Stock 11/27/2012   M   9,375 A $ 7.7 13,580 D  
Common Stock 11/27/2012   M   9,375 A $ 5.63 22,955 D  
Common Stock 11/27/2012   M   5,625 A $ 5.63 28,580 D  
Common Stock 11/27/2012   M   9,375 A $ 6.74 37,955 D  
Common Stock 11/27/2012   M   5,625 A $ 6.74 43,580 D  
Common Stock 11/27/2012   M   10,000 A $ 6.8 53,580 D  
Common Stock 11/27/2012   M   6,000 A $ 6.8 59,580 D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy) $ 15.04 11/27/2012   M     1,875 12/31/2006 09/11/2016 Common Stock 1,875 $ 0 0 D  
Stock Option (right to buy) $ 9.23 11/27/2012   M     1,407 09/30/2007 09/11/2017 Common Stock 1,407 $ 0 0 D  
Stock Option (right to buy) $ 7.7 11/27/2012   M     9,375 06/30/2008 05/21/2018 Common Stock 9,375 $ 0 0 D  
Stock Option (right to buy) $ 5.63 11/27/2012   M     9,375 06/30/2009 06/16/2019 Common Stock 9,375 $ 0 0 D  
Stock Option (right to buy) $ 5.63 11/27/2012   M     5,625 06/30/2009 06/16/2019 Common Stock 5,625 $ 0 0 D  
Stock Option (right to buy) $ 6.74 11/27/2012   M     9,375 06/30/2010 05/24/2020 Common Stock 9,375 $ 0 0 D  
Stock Option (right to buy) $ 6.74 11/27/2012   M     5,625 06/30/2010 05/24/2020 Common Stock 5,625 $ 0 0 D  
Stock Option (right to buy) $ 6.8 11/27/2012   M     10,000 06/30/2011 05/18/2021 Common Stock 10,000 $ 0 0 D  
Stock Option (right to buy) $ 6.8 11/27/2012   M     6,000 06/30/2011 05/18/2021 Common Stock 6,000 $ 0 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
EVNIN ANTHONY B
C/O VENROCK
530 FIFTH AVENUE, 22ND FLOOR
NEW YORK, NY 10036
  X      

Signatures

 /s/ Anthony B. Evnin   11/28/2012
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) On November 26, 2012, Venrock Associates III, L.P. ("VA3") and Venrock Associates, L.P. ("VA" and together with VA3, the "Venrock Funds") distributed an aggregate of 864,565 shares of the common stock of the Issuer to their respective partners pro rata based on their respective interests in the Venrock Funds (the "Distribution").
(2) Following the Distribution, the shares held by VA3, VA and Venrock Entrepreneurs Fund III, L.P. ("VEF3") are as follows: 235,312 shares held by VA3, 52,876 shares held by VA and 23,531 shares held by VEF3.
(3) Venrock Management III, LLC ("VM3") and VEF Management III, LLC ("VEFM3") are the sole general partners of VA3 and VEF3, respectively, and may be deemed to beneficially own the shares held by VA3 and VEF3, respectively. VM3 and VEFM3 expressly disclaim beneficial ownership over all shares held by VA3 and VEF3, respectively, except to the extent of their indirect pecuniary interests therein. Anthony B. Evnin is a member of VM3 and VEFM3. Dr. Evnin expressly disclaims beneficial ownership over all shares held by VA3, VA, VEF3, VM3 and VEFM3 except to the extent of his indirect pecuniary interest therein.
(4) In the Distribution, VM3 received 4,832 shares. For VM3, this represents a change in form of ownership from indirect to direct but does not represent a change in beneficial ownership.
(5) In the Distribution, Dr. Evnin received 923 shares. For Dr. Evnin, this represents a change in form of ownership from indirect to direct but does not represent a change in beneficial ownership.

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