PAGE  1
000 B000000 10/31/2010
000 C000000 0001267890
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 CLAYMORE DIVIDEND & INCOME FUND
001 B000000 811-21455
001 C000000 6305053700
002 A000000 2455 CORPORATE WEST DRIVE
002 B000000 LISLE
002 C000000 IL
002 D010000 60532
003  000000 N
004  000000 N
005  000000 N
006  000000 N
007 A000000 N
007 B000000  0
007 C010100  1
007 C010200  2
007 C010300  3
007 C010400  4
007 C010500  5
007 C010600  6
007 C010700  7
007 C010800  8
007 C010900  9
007 C011000 10
008 A000001 GUGGENHEIM FUNDS INVESTMENT ADVISORS, LLC
008 B000001 A
008 C000001 801-000
008 D010001 LISLE
008 D020001 IL
008 D030001 60532
008 A000002 MANNING & NAPIER ADVISORS, INC.
008 B000002 S
008 C000002 801-000
008 D010002 FAIRPORT
008 D020002 NY
008 D030002 14450
010 A000001 GUGGENHEIM FUNDS INVESTMENT ADVISORS, LLC
010 B000001 801-000000
010 C010001 LISLE
010 C020001 IL
010 C030001 60532
011 A000001 MERRILL LYNCH, PIERCE, FENNER & SMITH INC.
011 B000001 8-000
      PAGE  2
011 C010001 NEW YORK
011 C020001 NY
011 C030001 10080
012 A000001 BNY MELLON SHAREOWNER SERVICES
012 B000001 84-0000000
012 C010001 PITTSBURGH
012 C020001 PA
012 C030001 15252
013 A000001 ERNST & YOUNG LLP
013 B010001 CHICAGO
013 B020001 IL
013 B030001 60693
015 A000001 THE BANK OF NEW YORK MELLON
015 B000001 C
015 C010001 NEW YORK
015 C020001 NY
015 C030001 10286
015 E010001 X
015 A000002 ROYAL BANK OF CANADA
015 B000002 S
015 C010002 ONTARIO
015 D010002 CANADA
015 E040002 X
018  000000 Y
019 A000000 N
019 B000000    0
020 A000001 MERRILL LYNCH & CO., INC.
020 B000001 13-2740599
020 C000001     26
020 A000002 DEUTSCHE BANK SECURITIES CORP.
020 B000002 13-2730828
020 C000002     11
020 A000003 ISI GROUP
020 B000003 N/A
020 C000003      5
020 A000004 KNIGHT SECURITIES
020 B000004 91-0835748
020 C000004      2
020 A000005 WACHOVIA
020 B000005 34-1542819
020 C000005      1
020 C000006      0
020 C000007      0
020 C000008      0
020 C000009      0
020 C000010      0
021  000000       45
022 A000001 BARCLAYS BANK PLC
022 B000001 13-3551367
022 C000001       602
022 D000001       457
      PAGE  3
022 A000002 CITADEL TRADING GROUP L.L.C.
022 B000002 36-3667433
022 C000002         0
022 D000002      1057
022 A000003 MORGAN STANLEY & CO. INC.
022 B000003 13-2655998
022 C000003        66
022 D000003       817
022 A000004 WALL STREET ACCESS
022 B000004 13-3057481
022 C000004         0
022 D000004       800
022 A000005 STERN, AGEE, AND LEACH
022 B000005 N/A
022 C000005       709
022 D000005         0
022 A000006 BONDS DIRECT SECURITIES
022 B000006 95-4846556
022 C000006       191
022 D000006       474
022 A000007 BANAMAX SA (MEXICO)
022 B000007 N/A
022 C000007       300
022 D000007       300
022 A000008 CANTOR FITZGERALD & CO.
022 B000008 13-3680184
022 C000008         0
022 D000008       491
022 A000009 UBS
022 B000009 N/A
022 C000009         0
022 D000009       485
022 A000010 CREDIT SUISSE
022 B000010 N/A
022 C000010       452
022 D000010         0
023 C000000      76130
023 D000000     148137
024  000000 Y
025 A000001 MORGAN STANLEY
025 B000001 36-3145972
025 C000001 D
025 D000001     403
025 A000002 MERRILL LYNCH & CO., INC.
025 B000002 13-2740599
025 C000002 D
025 D000002     371
025 A000003 WELLS FARGO & CO.
025 B000003 41-0449260
025 C000003 D
025 D000003     213
      PAGE  4
025 A000004 JPMORGAN CHASE & CO.
025 B000004 13-2624428
025 C000004 D
025 D000004     216
025 A000005 GOLDMAN SACHS GROUP, INC.
025 B000005 13-5108880
025 C000005 D
025 D000005     598
025 A000006 DELETE
025 D000006       0
025 A000007 DELETE
025 D000007       0
025 D000008       0
025 D000009       0
025 D000010       0
025 D000011       0
025 D000012       0
025 D000013       0
025 D000014       0
025 D000015       0
025 D000016       0
025 D000017       0
025 D000018       0
025 D000019       0
025 D000020       0
025 D000021       0
025 D000022       0
025 D000023       0
025 D000024       0
025 D000025       0
025 D000026       0
025 D000027       0
025 D000028       0
025 D000029       0
025 D000030       0
025 D000031       0
025 D000032       0
026 A000000 N
026 B000000 Y
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 N
026 H000000 N
027  000000 N
028 A010000         0
028 A020000         0
028 A030000         0
028 A040000         0
      PAGE  5
028 B010000         0
028 B020000         0
028 B030000         0
028 B040000         0
028 C010000         0
028 C020000         0
028 C030000         0
028 C040000         0
028 D010000         0
028 D020000         0
028 D030000         0
028 D040000         0
028 E010000         0
028 E020000         0
028 E030000         0
028 E040000         0
028 F010000         0
028 F020000         0
028 F030000         0
028 F040000         0
028 G010000         0
028 G020000         0
028 G030000         0
028 G040000         0
028 H000000         0
030 A000000      0
030 B000000  0.00
030 C000000  0.00
031 A000000      0
031 B000000      0
032  000000      0
033  000000      0
035  000000      0
036 B000000      0
038  000000      0
042 A000000   0
042 B000000   0
042 C000000   0
042 D000000   0
042 E000000   0
042 F000000   0
042 G000000   0
042 H000000   0
043  000000      0
044  000000      0
045  000000 Y
046  000000 N
047  000000 Y
048  000000  0.850
048 A010000        0
048 A020000 0.000
      PAGE  6
048 B010000        0
048 B020000 0.000
048 C010000        0
048 C020000 0.000
048 D010000        0
048 D020000 0.000
048 E010000        0
048 E020000 0.000
048 F010000        0
048 F020000 0.000
048 G010000        0
048 G020000 0.000
048 H010000        0
048 H020000 0.000
048 I010000        0
048 I020000 0.000
048 J010000        0
048 J020000 0.000
048 K010000        0
048 K020000 0.000
049  000000 N
050  000000 N
051  000000 N
052  000000 N
053 A000000 Y
053 B000000 Y
053 C000000 N
054 A000000 Y
054 B000000 Y
054 C000000 N
054 D000000 N
054 E000000 N
054 F000000 N
054 G000000 N
054 H000000 Y
054 I000000 N
054 J000000 Y
054 K000000 N
054 L000000 N
054 M000000 Y
054 N000000 N
054 O000000 N
055 A000000 N
055 B000000 N
056  000000 N
057  000000 N
058 A000000 N
059  000000 Y
060 A000000 Y
060 B000000 Y
061  000000     2000
      PAGE  7
062 A000000 N
062 B000000   0.0
062 C000000   0.0
062 D000000   0.0
062 E000000   0.0
062 F000000   0.0
062 G000000   0.0
062 H000000   0.0
062 I000000   0.0
062 J000000   0.0
062 K000000   0.0
062 L000000   0.0
062 M000000   0.0
062 N000000   0.0
062 O000000   0.0
062 P000000   0.0
062 Q000000   0.0
062 R000000   0.0
063 A000000   0
063 B000000  0.0
066 A000000 Y
066 B000000 N
066 C000000 N
066 D000000 N
066 E000000 N
066 F000000 Y
066 G000000 N
067  000000 N
068 A000000 N
068 B000000 N
069  000000 N
070 A010000 Y
070 A020000 N
070 B010000 Y
070 B020000 N
070 C010000 Y
070 C020000 N
070 D010000 Y
070 D020000 N
070 E010000 Y
070 E020000 N
070 F010000 Y
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 Y
070 H020000 N
070 I010000 Y
070 I020000 N
070 J010000 Y
070 J020000 N
      PAGE  8
070 K010000 Y
070 K020000 N
070 L010000 Y
070 L020000 Y
070 M010000 N
070 M020000 N
070 N010000 Y
070 N020000 N
070 O010000 Y
070 O020000 Y
070 P010000 N
070 P020000 N
070 Q010000 N
070 Q020000 N
070 R010000 Y
070 R020000 N
071 A000000     33441
071 B000000     64791
071 C000000   1678507
071 D000000   26
072 A000000 12
072 B000000     1654
072 C000000     3695
072 D000000        0
072 E000000        0
072 F000000     1111
072 G000000       36
072 H000000        0
072 I000000       20
072 J000000       33
072 K000000        0
072 L000000      133
072 M000000      161
072 N000000       21
072 O000000        0
072 P000000      457
072 Q000000       52
072 R000000       43
072 S000000      275
072 T000000        0
072 U000000        0
072 V000000        0
072 W000000      205
072 X000000     2547
072 Y000000      105
072 Z000000     2907
072AA000000        0
072BB000000     1118
072CC010000    18170
072CC020000        0
072DD010000     3868
      PAGE  9
072DD020000      126
072EE000000        0
073 A010000   0.5600
073 A020000   0.0200
073 B000000   0.0000
073 C000000   0.0000
074 A000000      406
074 B000000        0
074 C000000     2837
074 D000000    20911
074 E000000      650
074 F000000    92082
074 G000000        0
074 H000000        0
074 I000000      248
074 J000000        0
074 K000000        0
074 L000000      494
074 M000000       77
074 N000000   117705
074 O000000        0
074 P000000       77
074 Q000000        0
074 R010000        0
074 R020000        0
074 R030000        0
074 R040000      135
074 S000000    33000
074 T000000    84493
074 U010000     4994
074 U020000        0
074 V010000    16.92
074 V020000     0.00
074 W000000   0.0000
074 X000000    16023
074 Y000000    76827
075 A000000        0
075 B000000    91319
076  000000    14.86
077 A000000 Y
077 B000000 Y
077 C000000 Y
077 D000000 N
077 E000000 N
077 F000000 N
077 G000000 N
077 H000000 N
077 I000000 N
077 J000000 N
077 K000000 N
077 L000000 N
      PAGE  10
077 M000000 N
077 N000000 N
077 O000000 N
077 P000000 N
077 Q010000 N
077 Q020000 N
077 Q030000 N
078  000000 N
080 A000000 ICI MUTAL INSURANCE COMPANY
080 C000000     5625
081 A000000 Y
081 B000000   7
082 A000000 N
082 B000000        0
083 A000000 N
083 B000000        0
084 A000000 N
084 B000000        0
085 A000000 Y
085 B000000 N
086 A010000      0
086 A020000      0
086 B010000   4086
086 B020000  66355
086 C010000      0
086 C020000      0
086 D010000      1
086 D020000  30000
086 E010000      0
086 E020000      0
086 F010000      0
086 F020000      0
087 A010000 COMMON STOCK
087 A020000 18385J105
087 A030000 DCS
088 A000000 N
088 B000000 N
088 C000000 N
088 D000000 N
SIGNATURE   JOHN SULLIVAN
TITLE       CFO & TREASURER