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Big Developments Set to be Unveiled at This Year’s San Antonio Breast Cancer Symposium (SABCS)

FN Media Group Presents USA News Group News Commentary

 

Vancouver, BC –November 30, 2022 – USA News Group  –  A new study has revealed that women diagnosed with benign breast disease through screening have an almost double risk of acquiring breast cancer. The findings come ahead of this year’s San Antonio Breast Cancer Symposium (SABCS), known as one of the largest breast cancer symposiums in the world. This year’s SABCS is already shaping up to contain some big developments, including data and presentations from biotech companies such as Oncolytics Biotech Inc. (NASDAQ:ONCY) (TSX:ONC), Eli Lilly and Company (NYSE:LLY), NeoGenomics, Inc. (NASDAQ:NEO), Zymeworks Inc. (NYSE:ZYME), and G1 Therapeutics, Inc. (NASDAQ:GTHX).

 

Ahead of the SABCS, which is scheduled for December 6-10, 2022, analysts at ReportLinker are projecting that the Global Breast Cancer Therapeutics Market is expected to grow by US$13.85 billion during 2022-2026, accelerating at a CAGR of 8.95% during the forecast period.

 

Set to present two new abstracts at the SABCS is Oncolytics Biotech Inc. (NASDAQ:ONCY) (TSX:ONC) through a pair of poster presentations, including interim results from a bridging clinical trial being conducted with partners Adlai Nortye, to evaluate Oncolytics’ flagship asset pelareorep in combination with paclitaxel in patients with advanced or metastatic HR+/HER2- breast cancer in one poster. The second poster will include data from a collaboration with SOLTI-Innovative Cancer Research from the AWARE-1 window-of-opportunity study in early-stage breast cancer patients. Full texts of the abstracts are available on the SABCS website.

 

Data published in the SABCS abstract indicates that pelareorep in combination with paclitaxel was safe, well tolerated, and showed anti-tumor activity in Adlai Nortye’s single-arm bridging clinical trial in Chinese patients with advanced or metastatic HR+/HER2- breast cancer. As of the abstract’s cut-off date, 10 patients were treated, with 4 achieving a partial response (PR) (2 confirmed, 2 unconfirmed), and 5 showing stable disease (SD).

 

This bridging trial is designed to accelerate Adlai Nortye’s development of pelareorep in China by allowing future regulatory submissions to include data from Oncolytics’ North American metastatic breast cancer trials, IND-213 and BRACELET-1.

 

Results from IND-213 showed a statistically significant near doubling of median overall survival in HR+/HER2- breast cancer patients treated with pelareorep plus paclitaxel compared to those treated with paclitaxel monotherapy. BRACELET-1 remains ongoing, with a readout on overall response rate, progression-free survival, and evolving overall survival data from the randomized phase 2 trial expected in the first half of 2023.

 

As for the AWARE-1 abstract, Oncolytics will be presenting results of gene expression analyses from cohorts 1 and 2, which exclusively enrolled patients with the HR+/HER2- breast cancer subtype who were treated with pelareorep and anti-cancer drug letrozole—with cohort 2 being with the PD-L1 checkpoint inhibitor atezolizumab and cohort 1 being without it.

 

Results published in the abstract showed that the studied combinations altered tumor microenvironments to induce and enhance anti-tumor immunity.

 

Biotech giant Eli Lilly and Company (NYSE:LLY) also announced that study investigators will present data from the company’s breast cancer portfolio and pipeline at the SABCS, including new results from studies of Verzenio® (abemaciclib; a CDK4/6 inhibitor), imlunestrant (an investigational oral selective estrogen receptor degrader [SERD]), and LOXO-783 (an investigational mutant-selective allosteric PI3Kα H1047R inhibitor).

 

For the Verzenio oral and poster presentations, LLY will provide updated clinical data from ongoing studies in early and advanced forms of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer.

 

Eli Lilly’s oral presentation will provide results from a pre-planned overall survival (OS) analysis from the Phase 3 monarchE study in HR+, HER2-, node-positive, high-risk early breast cancer, including four-year efficacy outcomes.

 

In another spotlight poster discussion, combination therapy results with imlunestrant will also be presented from the Phase 1 EMBER trial of imlunestrant in combination with Verzenio, with or without an aromatase inhibitor, in patients with estrogen receptor positive (ER+), HER2- advanced breast cancer.

 

In addition, pharmacodynamic data from the preoperative EMBER-2 trial evaluating imlunestrant in ER+, HER2- early breast cancer will be provided. Preclinical data with LOXO-783 in combination with standard-of-care breast cancer agents will also be presented at the meeting.

 

Oncology testing and global contract research services provider NeoGenomics, Inc. (NASDAQ:NEO) and its liquid biopsy-focused subsidiary, Inivata Limited are set to present new data at the SABCS that supports the use of their personalized, highly-sensitive sequencing test RaDaR®Assay across all types of early breast cancer in both the adjuvant and surveillance settings.

 

“The data being presented at SABCS adds to the growing body of evidence demonstrating the accuracy of RaDaR in detecting minimal residual disease and early disease relapse,” said Vishal Sikri, MBA, President and Chief Commercial Officer, Inivata, and President, Pharma Services, NeoGenomics. “We believe RaDaR offers great promise in breast cancer care as the detection of MRD and recurrence provides critical insights that can significantly impact patient care.”

 

RaDaR detects minimal residual disease (MRD) and recurrence, which are the trace amounts of circulating tumor DNA (ctDNA) that remain after surgery or other cancer treatment.

 

One study being presented compared the use of RaDaR to digital PCR (dPCR) in the surveillance setting in 161 patients with early-stage triple-negative breast cancer (TNBC). Among ctDNA-positive patients, more than half (55.2%) were first detected by RaDaR versus 5.2% by dPCR.

 

Clinical stage biopharmaceutical company Zymeworks Inc. (NYSE:ZYME) announced the publication of an abstract for their bispecific antibody zanidatamab, that can simultaneously bind two non-overlapping epitopes of HER2.

 

In combination with palbociclib and fulvestrant, zanidatamab was well tolerated, with encouraging and durable anti-tumor activity in heavily pretreated patients with HER2-positive HR+ breast cancer.

 

As per the trial, 34 heavily pretreated patients with HER2-positive HR+ breast cancer were treated with the zanidatamab+Palbociclib+fulvestrant combination, which resulted in a 34.5% confirmed objective response rate, with a 93.1% disease control rate in 29 response-evaluable patients.

 

Commercial-stage oncology company G1 Therapeutics, Inc. (NASDAQ:GTHX) will also be presenting at SABCS with initial results from its Phase 2 Trilaciclib Mechanism of Action (MOA) Trial, which is a 24 patient trial in early-stage TNBC.

 

G1 Therapeutics’s primary endpoints will assess the immune-based MOA, including the impact of Trilaciclib on CD8+ T cells and regulatory T cells, or Tregs, in the tumor microenvironment.

 

Secondary endpoints will include pathological complete response (pCR), immune response, and profiling measures. G1 will present initial results from the primary endpoint as a poster presentation during the 2022 SABCS.

 

For more information please visit: https://usanewsgroup.com/2020/02/24/why-biotechnology-companies-are-so-important/

  

Article Source: 

USA News Group
http://USAnewsgroup.com
info@usanewsgroup.com

  

DISCLAIMER: Nothing in this publication should be considered as personalized financial advice. We are not licensed under securities laws to address your particular financial situation. No communication by our employees to you should be deemed as personalized financial advice. Please consult a licensed financial advisor before making any investment decision. This is a paid advertisement and is neither an offer nor recommendation to buy or sell any security. We hold no investment licenses and are thus neither licensed nor qualified to provide investment advice. The content in this report or email is not provided to any individual with a view toward their individual circumstances. USA News Group is a wholly-owned subsidiary of Market IQ Media Group, Inc. (“MIQ”). MIQ has been paid a fee for Oncolytics Biotech Inc. advertising and digital media from the company directly. There may be 3rd parties who may have shares of Oncolytics Biotech Inc., and may liquidate their shares which could have a negative effect on the price of the stock. This compensation constitutes a conflict of interest as to our ability to remain objective in our communication regarding the profiled company. Because of this conflict, individuals are strongly encouraged to not use this publication as the basis for any investment decision. The owner/operator of MIQ own shares of Oncolytics Biotech Inc. which were purchased in the open market, and reserve the right to buy and sell, and will buy and sell shares of Oncolytics Biotech Inc. at any time without any further notice commencing immediately and ongoing. We also expect further compensation as an ongoing digital media effort to increase visibility for the company, no further notice will be given, but let this disclaimer serve as notice that all material, including this article, which is disseminated by MIQ has been approved by Oncolytics Biotech Inc.; this is a paid advertisement, we currently own shares of Oncolytics Biotech Inc. and will buy and sell shares of the company in the open market, or through private placements, and/or other investment vehicles.

 

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USA News Group is Source of all content listed above.  FN Media Group, LLC (FNM), is a third party publisher and news dissemination service provider, which disseminates electronic information through multiple online media channels. FNM is NOT affiliated in any manner with USA News Group or any company mentioned herein.  The commentary, views and opinions expressed in this release by USA News Group are solely those of USA News Group and are not shared by and do not reflect in any manner the views or opinions of FNM.  FNM is not liable for any investment decisions by its readers or subscribers.  FNM and its affiliated companies are a news dissemination and financial marketing solutions provider and are NOT a registered broker/dealer/analyst/adviser, holds no investment licenses and may NOT sell, offer to sell or offer to buy any security.  FNM was not compensated by any public company mentioned herein to disseminate this press release.

 

This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E the Securities Exchange Act of 1934, as amended and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. “Forward-looking statements” describe future expectations, plans, results, or strategies and are generally preceded by words such as “may”, “future”, “plan” or “planned”, “will” or “should”, “expected,” “anticipates”, “draft”, “eventually” or “projected”. You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events, or results to differ materially from those projected in the forward-looking statements, including the risks that actual results may differ materially from those projected in the forward-looking statements as a result of various factors, and other risks identified in a company’s annual report on Form 10-K or 10-KSB and other filings made by such company with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and FNM undertakes no obligation to update such statements.

 

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SOURCE USA News Group

The post Big Developments Set to be Unveiled at This Year’s San Antonio Breast Cancer Symposium (SABCS) appeared first on Financial News Media.

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